S1 - Madara oneshots both of them before they can react.
S2 - Sasuke solos
S3 - Probably Madara with high diff. He was doing well when faced with both Rinnegan Naruto & Sasuke, so half of that won't be enough to beat him. Itachi's fodder here other than for Izanami, though I doubt the most praised Uchiha that is Madara would have nothing to counter one of his clan's techniques, especially with the insight the Jubi would provide.