Sure, but evidence leads to a conclusion.
Dr. Gero's implications on how the humans and Piccolo's power would upgrade him make 50x a numerical impossibility.
1. Yamcha is a good source of power.
If someone only boosts you up less than half a percent, I doubt they'd say this.
2. Absorbing Piccolo, Gohan, Krillen, and Tien would allow for Dr. Gero to defeat Vegeta. This is impossible unless the humans are giving Gero a sizable boost. THe humans are below the Saiyans, so if a 50x boost was in play, it would cause major issues trying to make the humans relevant.
Numerically speaking, a 50x boost is impossible.
Gero being the foundation of your argument is problematic for two main reasons:
A) The inner workings of his absorption method are kind of a grey area, because although he absorbed ki from some of the Z Fighters, it's channelled through his mechanical energy source. So we're dealing with an energy system with undefined boundaries (excluding our knowledge that it's not an infinite energy type), and a situation that never even came into actuality (i.e. Gero not getting the chance to absorb all of them and for us to judge the resulting power-up).
B) His calculations were often proven wrong, both due to his overconfidence and lack of awareness. With that in mind, why does the 50x boost have to be what's at fault, and not Gero himself? There doesn't seem to be any merit in targeting Super Saiyan itself, while Gero saying something questionable or inaccurate falls in-line with how his character was portrayed on a regular basis.
It's also worth noting that although Gero turned out to be inferior to Piccolo and Vegeta, the extent of the difference isn't set in stone. So throwing around the term 'impossible' as if you have the blueprint to Gero's scaling seems far too assumptive.
