I can't see any difference. They pursue him unsucessfully for the following days, as in canon. Goku still brings up ROSAT, since the reason he did so in canon is that he and Vegeta sensed that Cell's chi is above unmastered SSJs. When Cell interrupts the fight Piccolo vs Seventeen, everything happens the same way until Cell absorbs Seventeen, which makes everybody realize that Cell absorbs androids, so Eighteen flees.
The only possible difference is that Vegeta does not know about absorptions, so, unless Cell happens to curse as in canon, thus making Vegeta curious to ask what he means, Vegeta just kills Cell. In that case, we have a 'no Buu' scenario (I have described this many times in the past).