Obviously, 100% Freeza would be 2nd form Cell tier and oneshot Galu :rape
In all seriousness, Goku's words suggested Freeza's stamina loss was purely due to his full power putting too much strain on his body rather than the Genki-Dama being a major factor, so it's most likely nothing would change. Assuming the strain was increased by the physical damage Freeza took though, he'd last long enough that Goku would be unable to escape the planet and die. In that scenario, he'd be revived on Earth by Porunga and, thus, never learn Shunkan Ido. This would raise the question of whether or not he'd get the heart disease, though I'll just say #17 and #18 kill him if assuming he got it on Yardrat.
This drastically changes the Cell Arc such as Goku not being able to save Ten and Piccolo. The biggest change would be that Cell's self-destruction goes unchallenged with him destroying the Earth and going around the universe looking to prove his perfection.