I'll go against the grain on this and say Gohan wins with medium difficulty. In his final fight, he was actually competent going against the Androids two on one. He was at a disadvantage from the start, having one arm as well as having to leave himself open against attacks more than one. With all of this, Gohan still managed to get in some good shots and block attacks, getting into short rhythms here and there but then having to drop his guard.
Against a suppressed version of 17 ad 18 here, I can see him taking this fight. He's got the higher battle power and no distractions.