By official PL's, a huge Kaio-Ken x4 Kamehameha might be able to do it, but if it didn't work he'd be out of energy. If he didn't do that, the Kaio-Ken x3 might let him last for a little while, but if he slipped to x2 he'd be toast. By my power levels, Goku doesn't have a snowball's chance in hell of even scratching that lobotomized bastard.