Jiren was the first to get knocked out.

[Pocket-Gog~]

Scenario 1. By being stupidly overconfident, Jiren is knocked out by one of the fighters, what changes?

Scenario 2. Goku is the 2nd one out.

 

[Void]

Kefla probably wouldn't be a thing because someone like Vegeta or Golden Freeza would've tossed Kale and Caulifla. GoD Toppo would probably win it all since Vegeta wouldn't get his new form from fighting Jiren. Ribrianne still blows.

 

[Captain Cadaver]

Things go pretty much the same for the most part other than when it comes down to just U7 VS U11 as Hit likely wouldn't have been eliminated due to none of the other fighters being able to counter Cage of Time. In the first scenario, Hit joins the U7 team to take down Hakaishin Toppo and is successful with help from Goku launching a Genki-Dama. By the end, Hit is nowhere near as fatigued as everyone else (bar #17) and his improvement ability would've allowed him to close in on Hakaishin Toppo's power, allowing him to solo. Vegeta may have still achieved SSBE due to Toppo's taunts, but I doubt he'd get the extra resolve boost and would've used up most of his stamina against Toppo. Hit wins and wishes everyone back, causing nothing to really change.

In the 2nd scenario, Toppo wins since Hit would be eliminated early on due to Goku not coming to help him out. Due to his flawed belief of Universe 7 having caused this catastrophe, he likely doesn't wish the other Universes back and instead wishes for evil to be erased from the 5 remaining universes so that they are all those of justice.