Which main villain do you think had the most impact

[Jerk Store]

It's gonna be Gogetto!

 

[Let's Go Fearless!]

It's gonna be Gogetto!

No.

 

[Jerk Store]

YES!!!!!! Or Vegerott!

 

[Let's Go Fearless!]

Raditz is underrated here.

 

[Victorious]

Freeza, pretty much all the events would not have happened if Freeza didnt exist.

Cell came and went in a few weeks, it was epic but it was just that.

Buu was super powerful and on a higher level than Freeza universally, but he's millions of years old...he had no impact on world events before he came.

 

[Tapion]

If we're talking about the entire franchise, Beerus obviously takes the cake with ease.
Early DB-only; King Piccolo without even trying.
Z-only: Freeza without even trying.